Biodistribution Studies
Precise analysis of the distribution, accumulation, and residence time of compounds within the organism to assess targeting efficiency and off-target exposure as a basis for safety evaluation.
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Preclinical Studies
Preclinical studies are the indispensable foundation for developing safe and effective drugs and therapies. Before any new compound enters the clinical phase, a precise, reliable, and meaningful evaluation - both in vivo and in vitro - is essential. With the highest scientific standards and state-of-the-art methodology, we support you at every stage of your project. Our focus is on tailor-made study designs that provide exact answers to your specific research questions.
Our Expertise & Core Focus Areas
Our extensive experience and proven expertise in the design and execution of specialized preclinical studies help you find the best models and guarantee professional services at all stages of your research project.
Core Focus Areas
Pharmacokinetics & Pharmacodynamics
Detailed determination of the time course of drug concentrations in the body (PK) and of the resulting biochemical and physiological effects (PD), with a particular focus on biomarker analysis as a quantitative readout of the pharmacological response.
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Advanced imaging techniques dedicated to longitudinal monitoring of reporter gene expression (optical imaging) or other drug effects (micro CT) within the same animal. This serial tracking provides high-quality data and reduces inter-animal variability.
Download PDFVaccination Studies
Evaluation of immunogenicity and efficacy of vaccine candidates, from mRNA and viral vectors to protein and peptide-based subunit vaccines, with additional experience in candidates formulated without traditional adjuvants.
Download PDFTumor Studies
In-depth investigation of oncology therapies with a particular focus on Tumor-PKs. We analyze local drug exposure and kinetics within the tumor microenvironment to ensure therapeutic impact where it matters most.
Download PDFHematology and Coagulation Studies
Characterization of bleeding disorders, treatment efficacy and pharmacokinetics in coagulation-deficient models (e.g. FVIII-KO, FIX-KO). Includes nail-clip, tail-clip and saphenous vein bleeding assays, a hemarthrosis model for studying hemophilic arthropathy, longitudinal running behavior tracking (Revolyzer) and standard or catheterized administration with sampling of plasma, serum, whole blood and organs.
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Study designs are tailored to your research question. Contact us to discuss what is not listed here.
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Contact us today to plan your next preclinical project with tailored study designs and professional execution at every stage.