Technology
Jess Western Blotting
Jess™ Simple Western is an automated high-throughput capillary-based immunoassay platform for rapid, sensitive, and quantitative protein analysis. Compared to conventional Western blotting, it delivers highly reproducible results with minimal sample consumption and reduced hands-on time.
The platform supports the multiplex detection of up to three targets within a single sample, making it particularly valuable for preclinical studies where sample availability may be limited. Our services support drug discovery, pharmacodynamics, biomarker evaluation, and animal model characterization in both rodent and large-animal studies.
Applications
| Application | Description |
|---|---|
| Target Protein Quantification | Quantitative measurement of protein expression in tissues, cells, and biofluids. |
| Animal Model Validation | Verification of knockout, knock-in, transgenic, and other genetically modified animal models. |
| Pharmacodynamic Biomarkers | Assessment of treatment-induced changes in protein expression. |
| Signaling Pathway Analysis | Quantification of total and phosphorylated proteins involved in key signaling pathways. |
| Target Engagement Studies | Confirmation of drug-target interaction and mechanism of action. |
| Biomarker Discovery & Validation | Evaluation of protein biomarkers associated with efficacy, disease progression, or toxicity. |
| Toxicology Studies | Monitoring of protein markers related to tissue injury and safety assessment. |
| Gene Therapy & Biologics | Analysis of transgene expression and therapeutic protein production. |
Key Features
- Fully automated capillary-based immunoassay
- Quantitative and highly reproducible results
- 3-Plex protein detection in a single sample
- Analysis of total and phosphorylated proteins
- Minimal sample volume requirements
- Sensitivity to the femtogram level
- Faster turnaround than conventional Western blotting
- Suitable for tissues, biofluids, and cell lysates
- Applicable to both rodent and large-animal models
- Ideal for pharmacodynamic, biomarker, and target engagement studies