Technology

Fluorescence Imaging

Capture the dynamic in vivo distribution of your therapeutics with exceptional temporal resolution. We offer tailored 2D optical fluorescence imaging to non-invasively and semi-quantitatively evaluate your delivery systems and biologics in real-time. Because fluorescence imaging utilizes an external excitation light source, it generates highly intense signals that can be captured in milliseconds. This enables true real-time image acquisition, allowing us to track rapid early-phase pharmacokinetics, target engagement, and vascular dynamics starting just moments after administration.

Applications

ApplicationDescription
Nanoparticle & Vector BiodistributionTracking the in vivo localization, early circulation kinetics, and clearance routes of NIR-labeled LNPs, liposomes, or viral vectors shortly after administration.
Targeted Biologics & AntibodiesEvaluating the target specificity, binding kinetics, and tissue accumulation of NIR-conjugated monoclonal antibodies, nanobodies, or receptor-targeting peptides in living models.
Vascular & Lymphatic DynamicsVisualizing rapid physiological processes like blood flow, vascular leakiness, or lymphatic drainage using fluorescent tracers, utilizing the real-time acquisition capabilities of fluorescence imaging.
Image-Guided InterventionsValidating fluorescent surgical probes and targeting agents designed to clearly delineate tumor margins or specific anatomical structures from surrounding healthy tissue.
Multimodal Fluorescence Imaging & Bioluminescence Imaging IntegrationBridging physical tracking and functional delivery: using fluorescence imaging to monitor the biodistribution of a vector (e.g., an LNP shell) and bioluminescence imaging to simultaneously confirm the translation of its genetic cargo.

Key Features

  • Real-Time Acquisition & Rapid Kinetics
  • Seamless Multimodal Integration (fluorescence imaging meets bioluminescence imaging)
  • Internal Multimodality (different Fluorophores)
  • Superior Throughput & Efficiency