Public-funded research projects and strategic collaborations driving innovation in diagnostics, antibody engineering, and gene therapy.
ProFit project establishing an improved platform for camelid antibody fragment (VHH) production for diagnostics and therapy. Using MRSA as a proof of concept, the project validates the "VHH immunojunction" technology in vivo and in vitro. Due to the pandemic, scope expanded to include therapeutic applications against SARS-CoV-2.
Funded by ProFit · EFRE · Brandenburg
ZIM cooperation project engineering specialized single-domain antibody (sdAb) libraries to pinpoint binders for novel tumor targets. Integrating tumor-specific sdAbs into Stratosvir's therapeutic virus construct to create enhanced viral immunotherapy.
Funded by BMWK · ZIM · Stratosvir
Transforming diagnostics by establishing a Point-of-Care alternative to complex clinical flow cytometry. Adapting a specific intracellular mechanism — where fluorescent camelid antibody fragments undergo proteasome degradation only when unbound — into a functional extracellular, cell-free system.
Funded by BMBF · PtJ
Developing two innovative pharmaceutical products delivering Botulinum Neurotoxin A as a nucleic acid instead of traditional protein form. An injectable formulation for movement disorders and a transdermal application for hyperhidrosis and wrinkles, utilizing gene therapy with targeted expression in the neuromuscular junction.
Funded by ILB · ProFit · EFRE
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